logo dha

DHA

24/02/2025
08:00
Horário oficial: Brasília

24/02/2025
Cardiologia
Português
logo dha

Seguindo

Sobre este conteúdo

Insulin resistance is associated to future hypertension in normotensive salt-sensitive individuals: a 10-year follow-up study

Sanchez, Ramiro A.; Sanchez, María J.; Pessana, Franco; More

Journal of Hypertension. 42(11):1915-1921, November 2024.

 

Background:

Salt-sensitive hypertension is associated with insulin resistance in nonobese individuals. However, no data have been reported for normotensive offspring of hypertensive salt-sensitive parents.

Aims:

To evaluate in normotensive salt-sensitive or salt-resistant offspring of hypertensive parents (offSS-HT and offSR-HT, respectively): the possible association between insulin resistance and endothelial dysfunction, and the risk of developing hypertension in a 10-year follow-up.

Design and methods:

Forty-one offSS-HT (29 ± 2 years; 20 female) and 36 offSR-HT (25 ± 3 years; 16 female) were followed up for 10 years. Both groups were considered lean. At baseline, creatinine clearance (CrCl), 24 h urinary albumin excretion (UAE), glycemia, and insulinemia were measured before and after 60 and 120 min of glucose overload (75 g). HOMA Index and the area under the curve (AUC) were calculated. Blood pressure (BP) and 24 h urine sodium excretion was measured annually. Postischemic minimum vascular resistance (forearm plethysmography) was assessed at baseline.

Results:

In offSS-HT, UAE (53 ± 3 mg/min) and CrCl (136 ± 8 ml/min) were higher in offSS-HT than in offSR-HT. (UAE: 12 ± 4 mg.min; p,0.01 and CrCl 107 ± 6 ml.min; P  < 0.01). An impaired vasodilatory postischemic response was observed in offSS-HT compared with offSR-HT ( P  < 0.01). In offSS-HT glycemia, insulin, AUC at 69 and 120 min post OTG were greater than in offSR-HT, p  < 0.02. In offSS-HT, blood pressure rose ( P  < 0.01) the 10 years follow-up compared with offSR-HT.

Conclusion:

Salt sensitivity in the offspring of hypertensive salt-sensitive individuals is associated with insulin resistance and endothelial dysfunction and is prone to hypertension over a short period of time.

 

Insulin resistance is associated to future hypertension in normotensive salt-sensitive individuals: a 10-year follow-up study

Sanchez, Ramiro A.; Sanchez, María J.; Pessana, Franco; More

Journal of Hypertension. 42(11):1915-1921, November 2024.

 

Background:

Salt-sensitive hypertension is associated with insulin resistance in nonobese individuals. However, no data have been reported for normotensive offspring of hypertensive salt-sensitive parents.

Aims:

To evaluate in normotensive salt-sensitive or salt-resistant offspring of hypertensive parents (offSS-HT and offSR-HT, respectively): the possible association between insulin resistance and endothelial dysfunction, and the risk of developing hypertension in a 10-year follow-up.

Design and methods:

Forty-one offSS-HT (29 ± 2 years; 20 female) and 36 offSR-HT (25 ± 3 years; 16 female) were followed up for 10 years. Both groups were considered lean. At baseline, creatinine clearance (CrCl), 24 h urinary albumin excretion (UAE), glycemia, and insulinemia were measured before and after 60 and 120 min of glucose overload (75 g). HOMA Index and the area under the curve (AUC) were calculated. Blood pressure (BP) and 24 h urine sodium excretion was measured annually. Postischemic minimum vascular resistance (forearm plethysmography) was assessed at baseline.

Results:

In offSS-HT, UAE (53 ± 3 mg/min) and CrCl (136 ± 8 ml/min) were higher in offSS-HT than in offSR-HT. (UAE: 12 ± 4 mg.min; p,0.01 and CrCl 107 ± 6 ml.min; P  < 0.01). An impaired vasodilatory postischemic response was observed in offSS-HT compared with offSR-HT ( P  < 0.01). In offSS-HT glycemia, insulin, AUC at 69 and 120 min post OTG were greater than in offSR-HT, p  < 0.02. In offSS-HT, blood pressure rose ( P  < 0.01) the 10 years follow-up compared with offSR-HT.

Conclusion:

Salt sensitivity in the offspring of hypertensive salt-sensitive individuals is associated with insulin resistance and endothelial dysfunction and is prone to hypertension over a short period of time.

 

Comentários

Deixe um comentário

SMC

26 Aulas
25 Horas
18 Aulas
10 Horas

Comentários

Deixe um comentário

[Dcc/Cp] Uti Cardíaca Pediátrica: Atualização 2020
Íntegra
13/08/2020
Thumb (7)
01:23:51
Vídeo
01/08/2024
[Dha Tv] Hipertensão E Diabetes

DHA

Íntegra
[Depeco Rs] Encontro De Ecocardiografia Do Departamento De Ecocardiografia  Da Socergs – Serviço Responsável: Passo Fundo
Íntegra
12/09/2020
Thumb Sbc Mt
Íntegra
06/10/2022
Thumb Smc
01:18:49

SMC

Vídeo
21/04/2024
[Dic] Aplicações Da Ecocardiografia Com Contraste

DIC

Íntegra
01/12/2020
Thumb (13)
18:03
Corte
27/05/2024
[Sbc - Mt] Tratamento Inicial Da Hipertensão Arterial Sistêmica - 14/06/22
Íntegra
14/06/2022
Sbc Ba
01:24:02
Íntegra
31/08/2023
Screenshot_1
21:51

DHA

Corte
24/04/2021
I Curso Online De Cardiologia Nuclear – Parte Iv
Íntegra
24/03/2021
Kit_Webinar_Socaba_Thumbnail_Podcast
Podcast
04/08/2023
[Dha Tv] A Importância Da Imunização No Paciente Hipertenso E Com Doença Cardiovascular

DHA

Íntegra
[Crtr 6] Saúde Mental Na Pandemia E No Pós-Covid - 17/09/21
Íntegra
17/09/2021
Carrinho de compras